reviewing the papers, it was clear that such a label claim could not be supported, and that it was a bit confusing to the consumer. What the label could say is "Clinically Proven to be Safe for 14 days," which reflects the design of the Xenadrine EFX papers. The research doesn't show any evidence of increasing the rate of fat lipolysis or any catalytic potential, it does show an increase in resting heart rate and thermogenic potential, supporting greater calories utilized. This evidence may support the prevention of weight gain under the direction of a controlled diet and exercise program. They seem to state the obvious in two of the papers available; "Weight control is mandated by two methods: reducing energy intake or increasing energy expenditure" now this is profound! In order to truly raise basal metabolic activity in order to burn fat is to directly stimulate or support the Thyroid hormone T3, which effectively oxidizes fat producing energy. This is one of the weaknesses of the Xenadrine EFX formula. There is no component(s) in Xenadrine EFX to support fat metabolism directly.
After a further evaluation of the formula I agree with the utilization of the ß-sympathicomimetics, which are a blend of adrenergic amines (synephrine, n-methyltryamine, hordinine, octopamine, tyramine) in the Bitter Orange extract. This will facilitate a greater potential for the utilization of energy substrates. Coupled with the energy yielding Seropro (cocoa extract yielding theobromine), which stimulates but doesn't over excite the central nervous system or interfere by extending the cyclic adenosine monphosphate levels, which may in turn cause irritability or sleeplessness. Cytodyne should be commended for the inclusion of these ingredients in their product.
On the other hand the composition of the remaining active ingredients for the Xenadrine EFX formula doesn't make as much sense structure function

wise. I see an extreme potential for over stimulation from neurotransmitter precursors; Tyroplex (l-tyrosine, acetyl-l-tyrosine), they are mainly for the production of a catacholamine known as norepinephrine an excitatory neurotransmitter that has no effect on fat metabolism and is generally inactivated by monoamine oxidase in the cell. Combined with the abundance of caffeine (green tea extract, yerbe mate), one may experience a feeling a trusty buzz. This combination could produce negative sensitivity; sleeplessness, irritability, and nervous energy that may leave a user feeling uncomfortable. If your sensitive to stimulants you should keep this in mind if you are considering taking any stimulant based weight loss product.
As a final observation, I noticed that the ingredient declaration and label copy did not support any of the patented or copyrighted raw materials that you often find in other top notch weight loss products. Inclusion of such ingredients often supports some clinical validation for effectiveness and technical support for credibility; this tells me that this probably did not occur because of production budgetary restrictions. This is where Xenadrine EFX falls a bit short. I wish they had put a bit more focus on quality and not necessarily quantity of ingredients.
In conclusion, the Xenadrine EFX by formula evaluation is a very respectable product but it has some slight loose ends from an ingredient quality standpoint. All in all, if you are watching your diet and doing some form of regular exercise you should find Xenadrine EFX to be helpful in rounding out your program.

About the Author
Peter Bracato is an avid health and fitness enthusiast and published author. Many of his insightful supplement articles can be found at the premier online health news magazine http://www.consumerhealthdigest.com