Are There Two Forms of Chronic Fatigue Syndrome?

A group of researchers have found a second type of chronic fatigue syndrome (CFS) with a biological foundation. They’ve named it “atypical” as opposed to “classical” CFS. Unlike classical CFS, it doesn’t necessarily become evident with classic flu symptoms such as headaches, muscle pain and difficultly concentrating. Instead it seems to be associated with triggers that happen months or years before CFS symptoms actually appear. It is also possible that atypical CFS may be followed my other ailments such as some types of cancer seizure-related ailments.

In a 32-person study of classical CFS patients, some were found to have the atypical form. The studies focused on cerebrospinal fluid samples. It was determined that those with the atypical form had past histories of viral encephalitis, foreign travel-related illnesses or a blood transfusion. Some later developed illnesses along with atypical CFS including cancer, seizure-related maladies, or even Gulf War-related ailments. This study also noted that the atypical subgroup had diminished capacities in their immune systems. The study concludes that there are biological indicators, or biomarker profiles, that could be used for detection. Using these profiles would allow for the identification and treatment of this complicated and mysterious disease in a more understood and effective fashion.