According to the American Cancer Society , about 76,000 Americans are diagnosed with melanoma every year. This least common form of skin cancer is responsible for the majority of skin cancer deaths and there is no drug or combination of drugs that can reliably treat It. That is why the news about successful trials with an active compound of a common hibiscus plant caused a huge interest in the media and among melanoma patients.
Hybiscus and melanoma
Scientists from the Texas Biomedical Research Institute studied the effects of gossypin on cell culture and mice. Gossypin is a flavone, an active compound of Hybiscus vitifolius, a common hibiscus plant. Researchers found that gossypin suppresses inflammation and growth of cancer cells, although it is not clear how. They published their findings in the recent issue of Molecular Cancer Therapeutics.
The researchers found that gossypin inhibits the activity of two gene mutations, which are common in people who have melanoma. They believe that gossypin has great potential as an inhibitor of mutations named BRAFV600E kinase and CDK4. These mutations are observed in the huge majority of patients with melanoma.
In the experiments with melanoma cell culture, researchers found that gossypin actually stopped growth of melanoma cancer cell that had the two gene mutations. Gossypin also stopped the growth of different human melanoma cells. Scientists concluded that gossypin in fact stopped the mutations by binding directly with them. Treatment with gossypin also reduced the volume of the tumor and significantly increased survival.
The researchers believe that their findings offer a new potential for a novel type of the treatment of melanoma. The next step in the research is to learn how the body reacts to gossypin and how it metabolizes and absorbs it.