CBD for Dogs: Drug Interactions to Be Aware Of

CBD for Dogs: Drug Interactions to Be Aware Of

CBD oil has recently grown in popularity in both human and canine treatments. The oil provides many health benefits with barely any side effects. However, just CBD for dogs is safe, that doesn’t mean that it can’t or won’t interact with other medications that you or your dog may be taking.

It’s crucial to know that CBD oil can enhance the effects of some drugs, but it can also block the actions of other drugs. One example of the blocking effect is similar to what happens when you eat grapefruit and take certain medications – the P450 enzyme is inhibited. This inhibition is caused by the CBD or grapefruit “using up” the enzyme.  This action stops the medication from being metabolized because those enzymes are no longer available.

Some medications susceptible to this are blood pressure medications, cholesterol medications, anxiety drugs, antihistamines, corticosteroids, and antibiotics. On the bright side, other medications can have an enhanced effect when combined with CBD. Anti-seizure medications may be more effective, for one. CBD may also contribute to pain relief, allowing for users to rely less on NSAIDs and opioids. Also, when CBD was combined with chemotherapy, cancer treatments were more effective. However, you should always address these issues with your vet before trying to treat your pet alone or combining medications with CBD.

Key Points:

  • Cannabidiol can make anti-convulsants more efficient at preventing seizures in patients.
  • Other than anti-convulsants, CBD enhances the effect of over-the-counter pain medications.
  • CBD can also enhance the effect of chemotherapeutic drugs used to treat cancer patients.


Like grapefruit, cannabinoids such as CBD may temporarily inhibit certain cytochrome P450 enzymes.

Denver CBD, organic, non-GMO, grown, non-chemical extraction, grown and bottled in the USA.

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HealthStatus Team

HealthStatus has been operating since 1998 providing the best interactive health tools on the Internet, millions of visitors have used our blood alcohol, body fat and calories burned calculators.

The HealthStatus editorial team has continued that commitment to excellence by providing our visitors with easy to understand high quality health content for many years.

Our team of health professionals, and researchers use peer reviewed studies as source elements in our articles.

Our high quality content has been featured in a number of leading websites, USA Today, the Chicago Tribune, Live Strong, GQ, and many more.
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HealthStatus has been operating since 1998 providing the best interactive health tools on the Internet, millions of visitors have used our blood alcohol, body fat and calories burned calculators. The HealthStatus editorial team has continued that commitment to excellence by providing our visitors with easy to understand high quality health content for many years. Our team of health professionals, and researchers use peer reviewed studies as source elements in our articles. Our high quality content has been featured in a number of leading websites, USA Today, the Chicago Tribune, Live Strong, GQ, and many more.

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