Duloxetine, Cymbalta

Duloxetine (Cymbalta) is an antidepressant medication, which works by blocking the reuptake of neurotransmitters to nerves in the brain. The inhibition of reuptake enables neurotransmitters, serotonin and norepinephrine, to remain present and effective in the brain, consequently reducing distressing psychiatric and physical symptoms.

Duloxetine may be used to treat several disorders, including depression, anxiety, and/or pain. Chronic pain disorders that may be treated with duloxetine include fibromyalgia, diabetic peripheral neuropathy, and musculoskeletal pain. Treatment with duloxetine requires medical evaluation and prescription by a healthcare professional.

There are several common side effects that should be monitored, as well as a potential for withdrawal symptoms if duloxetine is discontinued without tapering the dose gradually. Blood pressure should be monitored for hypertension. Both seizures and sexual dysfunction have been reported as possible side effects. Use of duloxetine in children or adolescents should be most cautiously considered, as it has been associated with both suicidal thoughts and suicide in these populations. Duloxetine should also not be used in breastfeeding women.

The oral daily dose may vary from 20mg to 120mg daily, depending on the disorder being treated. Often, the medication is started at a lower dose and advanced until a therapeutic dose is achieved. Duloxetine should be stored at room temperature.