Duloxetine, Cymbalta

Duloxetine, Cymbalta

Duloxetine (Cymbalta) is an antidepressant medication, which works by blocking the reuptake of neurotransmitters to nerves in the brain. The inhibition of reuptake enables neurotransmitters, serotonin and norepinephrine, to remain present and effective in the brain, consequently reducing distressing psychiatric and physical symptoms.

Duloxetine may be used to treat several disorders, including depression, anxiety, and/or pain. Chronic pain disorders that may be treated with duloxetine include fibromyalgia, diabetic peripheral neuropathy, and musculoskeletal pain. Treatment with duloxetine requires medical evaluation and prescription by a healthcare professional.

There are several common side effects that should be monitored, as well as a potential for withdrawal symptoms if duloxetine is discontinued without tapering the dose gradually. Blood pressure should be monitored for hypertension. Both seizures and sexual dysfunction have been reported as possible side effects. Use of duloxetine in children or adolescents should be most cautiously considered, as it has been associated with both suicidal thoughts and suicide in these populations. Duloxetine should also not be used in breastfeeding women.

The oral daily dose may vary from 20mg to 120mg daily, depending on the disorder being treated. Often, the medication is started at a lower dose and advanced until a therapeutic dose is achieved. Duloxetine should be stored at room temperature.

Key Points:

  • 1Duloxetine is an antidepressant that affects an individual’s neurotransmitters, specifically it prevents the re uptake of serotonin and norepinephrine.
  • 2Duloxetine can be used in treatment of a number of psychiatric disorders including, anxiety that is generalized and depression. In addition it is prescribed in some types of pain management.
  • 3Commonly known as Cymbalta, this drug does run the risk of some side effects. These effects include dizziness, loss in sexual appetite, digestive issues, and increased anxiety.


Many experts believe that an imbalance among neurotransmitters is the cause of depression as well as other psychiatric disorders.
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HealthStatus has been operating since 1998 providing the best interactive health tools on the Internet, millions of visitors have used our health risk assessment, body fat and calories burned calculators.The HealthStatus editorial team has continued that commitment to excellence by providing our visitors with easy to understand high quality health content for many years.
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HealthStatus has been operating since 1998 providing the best interactive health tools on the Internet, millions of visitors have used our health risk assessment, body fat and calories burned calculators. The HealthStatus editorial team has continued that commitment to excellence by providing our visitors with easy to understand high quality health content for many years.

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