Increasing weight loss per decade as people age from midlife to late life was associated with an increased risk of mild cognitive impairment (MCI), For women surviving into late life, the rate of weight loss over 20 years is associated with development of mild cognitive impairment (MCI) or dementia. The researchers found that the chance of developing MCI or dementia was increased for women with greater rate of weight loss over 20 years. Each 0.5 kg/year decrease resulted in 30 percent increased odds of MCI/dementia in age/education/clinic-adjusted base models. further adjustment for age, education, clinic, depression, and walking speed, each 0.5 kg/year decrease was associated with a 17 percent increased odds of MCI/dementia. Variability in weight was significant in base models. The odds of MCI/dementia were increased 11 percent for each 1 percent average deviation from each woman’s predicted weight curve. “Rate of weight loss over 20 years was associated with development of MCI or dementia in women surviving past 80 years.” adjustment the estimate was attenuated. community-dwelling women (mean baseline age: 68 and 88 at cognitive testing). Participants underwent body weight measures repeatedly over 20 years.

Key Points:

  • 1For women surviving into late life, the rate of weight loss over 20 years is associated with development of mild cognitive impairment (MCI) or dementia.
  • 2Researchers found that the chance of developing MCI or dementia was increased for women with greater rate of weight loss over 20 years.
  • 3In the study 1,289 older community-dwelling women underwent body weight measures repeatedly over 20 years.


For women surviving into late life, the rate of weight loss over 20 years is associated with development of mild cognitive impairment (MCI) or dementia, according to a study published online Dec. 19 in the Journal of the American Geriatrics Society.

Read the full article at: http://medicalxpress.com/news/2016-12-dementia-older-women-tied-year.html

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