Bipolar disorder<\/a> is most recognized by drastic mood changes among the individual. \u00a0 We all have mood changes at times precipitated by our good days and bad days, but a person with bipolar disorder, or manic depression, has extreme shifts in mood that are beyond the realm of just a \u201cbad mood\u201d or a \u201cgood mood\u201d. \u00a0 Their shifts are so extremely definable that it causes one to speculate that it is out of the ordinary. \u00a0 Their dramatic mood swings are of the ultimate \u201chighs\u201d and the deepest of the \u201clows\u201d.<\/p>\nA biochemical imbalance involving brain neurotransmitters and hormones seem to be largely responsible for developing a mood disorder. \u00a0 Because this involves many different genes, otherwise known as polygenic, it is difficult to say just where this imbalance will lead the person with a mood disorder. \u00a0 Almost 90% of people diagnosed with manic depression or bipolar disease has a relative with some type of mood disorder.<\/p>\n
Gene linkage techniques, published in a paper in 2003 by researchers, indicates a recognizable defect in a gene known as GRK3 as being responsible for one tenth of the instances of bipolar disorder. \u00a0 A kinase enzyme, known as G protein receptor kinase 3, plays a part in dopamine metabolism.<\/p>\n
A similar study done in 2007 links bipolar disease<\/a> and diacylglycerol kinase (DGKH), which is a significant protein in the aspect of lithium-sensitive pohosphatidyl inositol. \u00a0 According to yet another research it is thought that genes are also attributed to the age that a person develops bipolar disorder to occur earlier in each generation that it is passed down to and that is thought to be at an increasing rate of severity as well. \u00a0 This is known as genetic anticipation.<\/p>\n