Mestinon Reviews 2024: Mestinon Medication Benefits

Mestinon Reviews

The nerves control most of our bodily functions, but sometimes they might fail. If you can no longer handle some tasks that you were so good at, that’s a sign your nerves are failing you. This may occur due to the failed immune system that attacks nerves and muscle cells. One of the reasons for this is a condition known as Myasthenia gravis.

Myasthenia gravis is an autoimmune condition that causes muscle weakness. There is still no cure for the condition, but Mestinon for Myasthenia gravis can help manage the condition and enable people to have some semblance of a normal life.

Mestinon  for myasthenia gravis can also be used for POTs, and some studies have found that it helps increase the heart rate and alleviate symptoms. In this Mestinon uses review, we’ll cover Mestinon medication benefits, Mestinon side effects, the scientific research behind this medication, Mestinon long term effects of mestinon and Mestinon dosage.

To save you from the hustle in making the purchase decision, we have covered where to buy Mestinon and whether Mestinon over the counter medications is good for you.

What is Mestinon? 

Pyridostigmine (mestinon) is a cholinesterase inhibitor used to treat the symptoms of myasthenia gravis.

It also helps increase muscle strength in patients with myasthenia gravis, an autoimmune disease in which the immune system misfires and attacks the junctions between nerves and muscle cells.

Pyridostigmine (mestinon) is in a class of drugs called cholinergic antimyasthenics. It prevents the breakdown of a chemical called acetylcholine, which is needed to stimulate muscle movement. This is one of the most important mestinon uses.

Some symptoms of Myasthenia Gravis include;

  • Drooping eyelids
  • Shortness of breath
  • Slurred speech
  • Weakening muscles after physical activity
  • Blurred vision
  • Weak limbs
  • Facial impressions may change and look a bit off
  • Jaws get tired when you chew gum or hard foods like meat

How do you know if you have Myasthenia Gravis for sure?

If you have some of the symptoms above and you suspect it, you first need to see a doctor who will examine you. They will most likely ask you questions about how you feel and test your reflexes and muscle strength. They may also recommend the correct mestinon dosage.

You may also need to have some tests done, including;

  • Blood tests – these tests will check for antibodies like the acetylcholine receptor antibodies. But some people may not have the acetylcholine antibodies but instead have the Musk antibodies, which will confirm the diagnosis even in the absence of acetylcholine antibodies.
  • Tensilon Test – This is also known as the edrophonium test, and it involves injecting patients with edrophonium to increase acetylcholine levels in the neuromuscular joints. Unfortunately, this test is not performed in the US because the drug is not available.
  • Electrodiagnostic testing –This involves using needles on nerves or muscles to stimulate the nerves. If you have myasthenia gravis, repeated stimulation will make the muscles weak.



What is the product for

Treating Myasthenia Gravis


Pyridostigmine (mestinon)


A typical total daily dose is 600 mg (10 of the 60 mg tablets) 

In severe cases, one to three tablets Timespan 180 mg tablets once or twice daily.

✓ Oral solution: A typical total daily dose is 50 mL (10 5-mL teaspoons)

Form of Medication

Regular tablets
Extended-release tablets


It helps in improving muscle strength in people with myasthenia gravis


Prices start at $ 16.62 


What are Mestinon Ingredients?

The main active ingredient in Mestinon for pots is Pyridostigmine. Mestinon dosage comes in three strengths, and while some ingredients are the same in all of them, some are unique to a specific strength.

The common ingredients are;

  • Colloidal anhydrous silica
  • Magnesium Stearate

Pyridostigmine (mestinon) 10mg contains 10 mg of pyridostigmine bromide as the active ingredient. 

It also contains:

  • Maize starch
  • Lactose monohydrate
  • Purified Talc
  • Pregelatinized potato starch

MESTINON 60mg contains 60 mg of pyridostigmine bromide as the active ingredient. It also has:

  • Maize starch
  • Purified Talc
  • Povidone
  • Acacia
  • Iron oxide red CI77491
  • Iron oxide yellow CI77492
  • Magnesium stearate
  • Pregelatinized potato starch
  • Liquid paraffin
  • Hard paraffin
  • Sucrose
  • Rice starch

Pyridostigmine (mestinon) Timespan 180mg contains 180 mg of pyridostigmine bromide as the active ingredient.

  • Carnauba wax
  • Calcium phosphate
  • Zein

So now, let’s delve a little deeper into the ingredients

Maize starch 

Maize starch  Maize starch is white with almost no smell or taste. Just like all the other starches, it is used as a stabilizer. The starch is extracted via wet milling, purified, and then dried.

Colloidal Anhydrous Silica

Colloidal Anhydrous Silica Colloidal anhydrous silica is an oxide of silicon made by hydrolyzing a silicon compound. It has the same formula as amorphous and crystalline silica, but they are natural. Colloidal anhydrous silica is mostly white, light, and very light powder.

When used in medicine, it acts as an anticaking agent and an adsorbent (used to purify the other ingredients). It is always inert, and its insolubility ensures it is not absorbed into the bloodstream but is excreted in waste as it goes in. This is a quality that make it great for the main mestinon uses.

Lactose monohydrate

Lactose monohydrate Lactose Monohydrate is a sugar found in milk, and its chemical structure makes it ideal to be processed as a powder and used as a stabilizer for sweetening or a filler. In medication, like mestinon for myasthenia gravis it is used as a filler.

Lactose monohydrate is easily compatible, making it suitable for making tablets that are easy to swallow. 

Can people with lactose intolerance take tablets with this ingredient? The answer is yes because while it contains lactose, there isn't enough lactose in mestinon dosage to create issues for most lactose-intolerant people. 

However, if you are allergic to lactose, that is another issue, and you may need to stay away from products with lactose because it doesn’t take much to cause an allergic reaction.

Purified Talc

Purified Talc Purified Talc is hydrated magnesium silicate. It is used as an anti-clumping agent in tablets to prevent the ingredients from clumping together and sticking to the machines manufacturing the tabs. Natural Talc is usually contaminated with asbestos which is dangerous and can increase the risk of cancer.

That is why in these mestinon for myasthenia gravis tablets, it is purified to make sure it is safe. Purified Talc is also generally recognized as safe (GRAS) by the FDA.

Magnesium Stearate

Magnesium Stearate Magnesium Stearate is a sticky white powder that is greasy to the touch, and it is made of stearic acid (a saturated fat) and magnesium. Stearic acid naturally occurs in eggs, walnuts, salmon, coconut oil, chocolate, palm oil, and cheese.

In medication like mestinon for pots, it is used as a flow agent and improves the quality and consistency of the capsules. Magnesium stearate also slows down the absorption of tablets and ensures they are absorbed in the right bowel area.

Pregelatinized potato starch

Pregelatinized potato starch Starches are powders from plants with starch, and they are mainly used as thickening or stabilizing agents. Pregelatinized starches are pre-treated with heat, making them swell when you add cold water.

Pregelatinized potato starch is made when potatoes are mashed, sieved, and dried. They are also centrifuged and heated. In medication, the starch is used as a filler to stabilize the capsules and tablets.

Liquid Paraffin

Liquid Paraffin is a transparent and almost odorless liquid obtained from petroleum and is also known as mineral oil. As a supplement, it is used to soften stool and ease constipation, and it can also be used topically to treat skin conditions.

Hard Paraffin

Hard Paraffin Hard paraffin is crystalized hydrocarbons gotten from petroleum. It is off-white and has several uses. Synthetic paraffin wax started being used for commercial purposes after World War II. 

In Pyridostigmine (mestinon), it is used because it is absorbed as it can help slow down the breakdown and absorption of drugs. This makes the mestinon dosage more effective.


Sucrose Sucrose is a disaccharide made up of equal parts of the fructose and glucose monosaccharides naturally occurring in plants. It is also the main ingredient in table sugar and is commonly used as a sweetener in many processed foods. 

Some of the plants with sucrose include; sugarcane, dates, sugar beets, honey, and sugar maple sap. 

It is used as a sweetener in Pyridostigmine (mestinon) because it is not the best tasting.

Rice Starch

Rice Starch is also used as a binding and stabilizing agent to keep the tablets together.

Iron oxide red CI77491 and Iron oxide yellow CI77492

Iron oxide red CI77491 The FDA has approved red and Yellow oxide as Exempt from certification or natural, and they are used as a colorant in many processed foods. Most other natural colors are usually unstable and are very challenging when used in formulations. 

Iron oxides are great to use as synthetic colors, and the red and yellow oxides can be blended to create a few shades. They are also cost-effective because their color tints are intense, and you need less of them to get the right level of pigment. There are also guidelines on using them outlined by the Good Manufacturing Practices (GMP) making the long term effects of mestinon safe.

The iron oxides also plate similar to a synthetic lake, making them great for coloring compressed tablets.

Calcium Phosphate

Calcium Phosphate Calcium phosphate, also known as tricalcium phosphate, is a compound made of calcium and phosphorous. It is abundant in our teeth and bones. Calcium can be found in the body tissues and the circulatory system. Phosphorous is also vital in DNA and proteins. It is also beneficial in mestinon for myasthenia gravis.

Calcium supplementation can be necessary for people with the following conditions;

  • Osteoporosis – a condition that arises when bone minerals and density reduce and can make people susceptible to bone fractures.
  • Vitamin D deficiency – Vitamin D helps in calcium absorption. Most times, the deficiencies of both minerals goes together. 
  • Hypocalcemia – blood calcium deficiency
  • Hypoparathyroidism – This condition occurs when the body doesn’t produce enough parathyroid hormone. The hormone is responsible for maintaining a balance in phosphorous and calcium levels in the body.

Carnauba Wax

Carnauba wax You may be surprised that this ingredient is edible, but it is. It has food-grade versions that give tablets their shine and keep them from melting or breaking down. 

The wax comes from the carnauba tree found in Brazil. The leaves are harvested and beaten for the wax, and the wax is then bleached to make it usable for various things.


Zein This is a protein found in corn. It is clear, insoluble in water, and has no taste or odor when it is pure. It is used as a coating and is preferred to other ingredients since it is natural.

It is also classified as GRAS by the FDA.

How does Mestinon work? How good is the effect of Mestinon?

Over the years, Mestinon has been known to be very effective when it comes to treating people with myasthenia gravis. If you follow the directions on your prescription carefully, you will quickly get the result faster. Mestinon works effectively within hours of taking them. 

How to use Mestinon for the best results? – How much Mestinon should you take?

How much Mestinon should you take The number of mestinon 60mg tablets you take depends on the strength of the medicine. Also, the interval between doses should be at least six hours, and the length of time you take the treatment depends on the medical problem for which you are taking these medicines.

The usual adult dose is one to three Mestinon 60mg tablets two to four times daily. In severe cases, one to three Mestinon Timespan 180 mg tablets once or twice daily.

If you have difficulty eating, your doctor will adjust your mestinon dosage so that you may need to take larger doses at times of greatest fatigue, e.g., 30-45 minutes before meals.

The long term effects of mestinon studies shows it should be taken for a few weeks for the symptoms to change.

How long does it take for Mestinon to work?

The  Mestinon otc tablets take 30-60 minutes to start working, and their effect will last for about 4-6 hours. This is why it is essential you take the pills every 4 to 6 hours to ensure the mestinon 60mg drugs aren’t entirely depleted from your system, and you can function as normally as possible.

Mestinon Medical Opinions 2024: Is Mestinon safe to use?

Is Mestinon safe to use Mestinon otc is one of the oldest medicines being used now. It was developed hundreds of years ago before clinical trials were a thing. Most of the studies were done after it was already in use, but they are positive.  Most of them show that Mestinon for POTs and Mestinon for myasthenia gravis are great for treating these conditions. They also show that the long term effects of mestinon are positive.

Mestinon Side Effects

The most common Mestinon side effects include nausea, diarrhea, vomiting, abdominal cramps, upset stomach, excessive sweating, muscle cramps, and muscle weakness.


When you visit your doctor, you should let them know all other medications you are taking and any allergies you have. Mestinon60 mg has indications with some other medications. It will either affect how these drugs work, or they will affect how it works. They will also determine the long term effects of mestinon.

Other Conditions 

Also, let your doctor know if you have any other conditions, especially asthma and kidney disease. Pregnant women are also not advised to take this drug.  If you are going to have surgery, also let your doctor know to let you know the way forward.

Mestinon results before and after: do Mestinon really work, or is it a fake?

Mestinon results after two weeks

Some people may experience Mestinon side effects the first few times they take the medications, but they should wear off in a few days. 

Mestinon results after one month

Your body should have gotten used to you taking the meds, and your condition should start to stabilize.

Mestinon results after two months

Your crash episodes may stop being as devastating as before you started taking them. Your energy levels should also increase, and you should be able to participate in your day-to-day activities without too much strain. This is a great manifestation  of mestinon uses.

Mestinon results after two weeks The first week can be a nightmare because there may be some Mestinon side effects before your body gets used to the meds.
Mestinon results after four weeks Your body may start to get used to the meds, and you should begin to feel the benefits like increased energy and muscle strength when using mestinon 60mg.
Mestinon results after six weeks Some people experience almost crippling weakness, but after a few weeks of taking Mestinon, these feelings of extreme muscle weakness become less debilitating. 
Mestinon results after eight weeks Your condition should continue to improve and stabilize.

Our Mestinon reviews and rating: Mestinon pros and cons: 

All medications have their good side and not so good side. Let’s look at the two sides of Mestinon generic.


  • First choice treatment for myasthenia gravis
  • The extended-release tablet is taken once or twice daily
  • Available as an oral solution if you need small mestinon generic dose changes or have difficulty swallowing pills
  • Few Mestinon side effects, unless you take too much
  • Available as a lower-cost, generic form


  • Treats the symptoms of myasthenia gravis but not the underlying condition
  • Immediate release tablet and oral solution forms are taken multiple times a day
  • Taking too much can lead to various side effects, including muscle weakness

Mestinon Positive Reviews

Mestinon Positive Review 1

Mestinon Positive Review 2

Mestinon Negative Reviews

Mestinon Negative Review

Mestinon reviews on the internet and forums like Reddit or Consumer Reports:

Mestinon reviews on the internet and Forums The internet is a treasure trove of information on everything, including medications. Reddit is especially great because it has specific threads for information about Mestinon generic. There are many good reviews with users ecstatic about how much better they feel.

Is Mestinon reputable, or are there any warnings about Mestinon on the internet? 

Warnings about Mestinon Mestinon generic is reputable and has been around for years. It is one of the oldest medications that are still in use today. Most of its users have had a good experience with it, and it helps them deal with their condition and improves their quality of life.

What do I need to consider if I want to discontinue Mestinon?

You do not need to stop taking your medication abruptly unless your consultant neurologist tells you to, even if you feel well. The length of time you will be taking this medication depends on your needs.

Where can you buy Mestinon over the counter? Mestinon price comparison & deals for sale:

Mestinon price comparison & deals for sale It is highly recommended that you buy Mestinon online, although you can still find it in some pharmacies. When you buy this medication online, you will get favorable deals there.

Can you buy Mestinon in a pharmacy?

Buy Mestinon in Pharmacy Yes, you can get Mestinon generic at the pharmacy, but we have a better idea. You can buy Mestinon online on the Web Rx 24 website. In some cases you can even find mestinon without prescription.

Mestinon Review Conclusion - Our experience and recommendation:

Finding out you have an autoimmune disease can be devastating. And finding out you may need to be on medication for a considerable chunk of your life just to function normally can be a bit much to take in.

But it can be comforting to know the medication you are taking will help you feel better and is safe for you at the same time. Our research has shown that Mestinon generic has excellent ingredients to make it palatable and effective. 

Most of its users are happy with their health progress. Another thing we like is that you can buy mestinon online and also get mestinon without prescription if you are sure you have myasthenia gravis. The mestinon cost can be a bit high but worth it given the benefits and that you can fond mestinon for sale easily.

Mestinon experience and recommendation

Frequently asked questions about Mestinon:

What is Mestinon?

What does Mestinon do?

How to take Mestinon?

How much does Mestinon cost?

Where can I buy Mestinon without a prescription? (Refer to our partner provider).

Are there any criticisms of Mestinon, or is it recommended to take Mestinon?

Does Mestinon have any risks or side effects?

Is it safe to take Mestinon continuously?

Do I need a prescription to buy Mestinon?


Written by Dr. Nick Willson PhD
Medical Writer & Editor

Dr. Nick Willson is a medical professional with over 10 years experience in nutrition holding a PhD in Foods and Nutrition at Purdue University, IN, USA. Dr Nick is a well known medical author and his work has been published on a number of medical publications including and Google Scholar. His clinical research specialises in investigating nutrition-related medical conditions from obesity down to eating disorders like anorexia and bulimia. He has carried out extensive research into how food supplements can enhance and help to sustain weight loss in patients. His passion for nutrition has led Dr Nick to start this website in order to spread his knowledge and help other individuals in their weight loss journey.

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