Periactin Reviews 2024: Periactin Medication Benefits

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Periactin, also known as Cyproheptadine, is a first-generation antihistamine with antiserotonergic, anticholinergic, and local anesthetic effects. It was invented in 1959 and first used in medicine in 1961.

Periactin is an antihistamine used to treat allergy symptoms, including watery eyes, itchy eyes and nose, runny nose, hives, sneezing, and itching. The data suggests that it is useful for this purpose, although second-generation antihistamines like ketotifen and loratadine have demonstrated comparable efficacy with fewer side effects.

What is Periactin?

Periactin is an antihistamine that is often used as a migraines preventative therapy. In a 2013 research, a patient’s migraine frequency was significantly decreased after 7 to 10 days of initiating medication. The average number of migraine episodes in these individuals before therapy was 8.7 times per month. However, this was reduced to 3.1 times per month three months later.

It can also be used off-label in the therapy of periodic vomiting disorder in babies, with only previous studies supporting its usage. Periactin is well absorbed after oral administration and reaches peak plasma levels after 1-3 hours. The terminal half-life, when taken orally, is about 8 hours.

Periactin was studied in a small study as an add-on for people with schizophrenia who are stable and taking other medications. Several studies have been conducted to determine whether Cyproheptadine reduces sexual dysfunction caused by SSRIs and antipsychotics. It is being studied for the treatment of post-traumatic stress disorders.




Themis Pharmaceuticals Ltd.


✔️ Stimulates appetite and reduces muscle waste,

✔️ Periactin has been used as a preventative measure against migraine headaches in children and adolescents, 

✔️ Treatment of Excessive Vomiting,

✔️ Improvement of Certain Skin Conditions,

✔️ Relief of Side Effects of Some Antipsychotics,

✔️ Periactin may be a helpful withdrawal symptom from baclofen and benzodiazepines, 

✔️ Helps treat Cushing's disease,

✔️ Improves attention and fluency.

Side Effects

There is no such potential risk unless you have an asthma attack, are old, or have a disability.


3 to 4 hours

Age Range

From 7 years old to adults


Periactin's average retail price is $ 53.77.



What are Periactin Ingredients?

All ingredients of Periactin are natural, and there are no reports of negative side effects except for those who may be allergic to it. The combination of these components helps keep your body’s performance at peak levels. The main components of this supplement are:

  • Cyproheptadine: It is a highly effective antihistamine and inverse antagonist of the Specific receptors. It also possesses anticholinergic, antiserotonergic, and antidopaminergic properties at greater dosages. It is a particularly powerful antagonist of the 5-HT2 receptors among the serotonin receptors. Cyproheptadine was tested as an adjuvant in patients with schizophrenia who’ve been stable and on other medication in one short experiment; while attention and language comprehension appeared to improve, the research was too small to make conclusions from.
  • Maize starch: Maize starch is a non-adhesive agent suitable for natural latex medical products such as condoms, diaphragms, and medical gloves. Cornstarch contains qualities that enable the delivery of glucose to maintain blood sugar levels in people with glycogen storage disorders such as Sugar Balance. Corn starch can be administered as early as 6–12 months of age to prevent glucose swings. Maize starch is included in the FDA’s list of generally accepted food substances.
  • Pregelatinized maize starch: Pregelatinized starch is a common medicinal aid, particularly as a filler-binder. It is well recognized that the source of excipients might alter their tableting ability. This substance has the smallest particle size, the highest porosity, the highest density, and the best flow.
  • Calcium hydrogen phosphate dihydrate: Calcium hydrogen phosphate dihydrate is utilized in the production of pharmaceutical dosage forms as well as in nutritional supplements as a calcium and phosphorus source.
  • Lactose monohydrate: Lactose monohydrate is a crystalline form of lactose. It’s often used as a filler in pharmaceuticals and as a sweetener or stabilizer in packaged meals, baked products, and baby formulae. This ingredient is largely regarded as harmless, and people who are lactose intolerant may not experience any symptoms.
  • Magnesium stearate: Magnesium stearate is a filler commonly found in medicine capsules. It’s referred to as a “flow agent.” It keeps the capsule’s separate components from clinging to each other and the capsule-making equipment. It assists with pharmaceutical capsule uniformity and quality control.
  • Lactose: It is a disaccharide consisting of galactose and glucose molecule. In the pharmaceutical industry, lactose is used in the formation of tablets due to its excellent compressibility. It is also used in the production of diluted powders for inhalation of dry powders. Lactose can be listed as hydrous lactose, anhydrous lactose, lactose monohydrate, or spray-dried lactose.


How does Periactin work? How good is the effect of Periactin on weight gain?

Periactin mainly works by inhibiting the production of a natural chemical by your body when in an allergic response. This drug also inhibits another naturally occurring chemical in your system. Do not use this medicine for newborns or premature babies.

Periactin is classed as a first-generation antihistamine since it operates by suppressing the effects of histamine. Histamine is created or produced by cells in the body during allergic responses and, to a smaller extent, during viral infections like the common cold. When histamine connects to receptors on other cells, it causes changes within the cells, releasing chemicals that can cause sneezing, itching, and increased mucus production.

Antihistamines compete for cell receptors with histamine and attach to them without activating the cells. Furthermore, they inhibit histamine from connecting to and activating cells. Periactin also inhibits the activity of acetylcholine and serotonin, two neurotransmitters used by neurons and muscles to communicate.

Periactin is an antihistamine and serotonin antagonist, was contrasted to placebo in healthy, underweight people for its efficacy in stimulating hunger and increasing weight gain. The increase in appetite and weight was statistically more significant in individuals who got Cyproheptadine.

According to a study published in the Journal of Pediatric Gastroenterology and Nutrition, it is used as an appetite suppressant to assist adults and children gain weight. It is typically used for underweight people who have a loss of appetite.


How to use Periactin for best results? How much Periactin should you take?

You should follow the doctor’s instructions and take this medicine in your mouth with or without food. If you take this medication in liquid form, accurately measure the dose using only the proper measuring spoon. If you want to use a regular spoon to measure it, you may not obtain the exact amount.

The dose is determined by your age, health condition, and treatment response. The dose may also be determined by children’s body shape and weight size. Do not raise your dose or use this drug more frequently than prescribed.

Periactin is available in tablet and liquid form, so you won’t have to bother about needles or obtaining a doctor’s prescription. Simply follow the directions on the bottle for the recommended dose; if you’re stacking supplements, make sure to follow the instructions for each one separately. Take the tablets with lots of water or fruit juice but avoid alcohol and carbonated drinks while taking the capsules.

Take 4 milligrams of this pill three times a day with water. You should not take more than 16 mg of this pill per day. A total of 15 pills are contained in each box. To get the most out of the supplement, take it for at least two months. For best results, use the right recipes and diet plans. 

How long does it take for Periactin to work?

This drug doesn’t take too much time to work. It works fast, it takes around 1 to 2 hours, and in this period, clinical symptoms should improve.

How long does it take for Periactin to work?

Periactin Medical Opinions 2024 : Is Periactin safe to use?

Periactin is generally considered tolerable, especially when compared to previous medications. Periactin is an inexpensive drug readily available worldwide and can be taken orally or in liquid form. This makes it suitable not only for hospital use but also for home use. Compared to other drugs in this category, it has excellent absorption and tissue distribution and is especially effective in critically ill patients. 

A very versatile drug with a wide range of actions and a wide range of therapeutic uses. Many clinical trials were conducted before official approval. Rest assured that it is entirely safe to consume and does not pose a severe threat to your overall health.

Periactin Side Effects

Sleepiness, increased hunger, and dry mouth is common adverse effects. Otherwise, there are no such hazardous compounds or any unfavorable repercussions to be concerned about. The company conducted an investigation and discovered that there were no severe negative effects or concerns associated with the medication’s use.

safe to use?

Periactin results before and after: do Periactin really work, or is it a scam?

Periactin inhibits histamine receptors and halts the chain reaction, which can induce allergic symptoms. It is referred to be a sedating antihistamine since it penetrates the brain in large amounts and produces sleepiness. Because of this and its antihistamine function, Cyproheptadine is beneficial for alleviating itching caused by allergies, chickenpox, or eczema. It might be especially beneficial for itching that worsens at night.

Duration Result
After 2-3 hours ✔️ Gives relief from allergy symptoms
After two weeks ✔️ Prevents watery eyes, runny nose, sneezing, itching nose, hives, and itching
After two months ✔️ Completely eliminates allergic reactions.

happy group

Our Periactin reviews and rating: Periactin pros and cons:

Pros of Periactin:

  • Improves chemical intolerance of organic phosphate.
  • Improves digestion.
  • Helps to stop the bleeding. 
  • Cyproheptadine may reduce ACTH
  • Helps to reduce depression. 
  • Has antiandrogen properties. 
  • Improves attention and fluency. 
  • Reduces side effects of some antipsychotics. 
  • Fight migraines and headaches.
  • Treat excessive vomiting and allergies.

Cons of Periactin:

  • Do not use it for pregnant and lactating women. 
  • Not recommended for a child under the age of 2. 
  • The dosage depends on the infection.

Periactin positive reviews

Customers who've already purchased and utilized Doxycycline have shared their delight. Many individuals have shared their stories on health forums and in the news about how difficult it was to gain weight, get rid of allergy symptoms, and how Periactin has changed their lives. Those who have used it and those who have recommended it both laud its safety and effectiveness. Some people said that they never thought they could get over 110 pounds, but these pills had them eating whole cakes in one day.

Periactin negative reviews

There have been no reports of Periactin-related problems at the time of writing this article. So yet, just a few people have expressed dissatisfaction with the medication's results. Each person is affected differently by the medicine. Some individuals claim it works instantly, while others claim it takes a long time. In general, Periactin should not be taken for a long period before noticing results.

Our Periactin reviews and rating: Periactin pros and cons:

Periactin reviews on the internet and forums like Reddit or Consumer Reports:

It has been extensively noted that the broad usage of Periactin by a large number of people benefits the general populace. Many individuals are now discussing their experiences with Periactin online and in groups like Reddit on how to manage pain in such a safe and inexpensive method. Others claim they just use this medicine to gain weight.

Periactin has been shown to be useful in the treatment of relieving allergy symptoms, the most prevalent ailment that individuals have been able to overcome. People have expressed their delight at how rapidly they were able to alleviate their allergy difficulties.

Periactin has a few disadvantages, but it also has a lot of favorable customer comments. Periactin has received highly positive feedback on several websites. The majority of clients give favorable feedback, claiming that it helps them reduce their allergic reaction levels to zero.

Is Periactin reputable, or are there any warnings about Periactin on the internet?

Periactin should not be used if you are allergic to it. To be utilized properly, it may need a dose adjustment or extra testing. Periactin has the potential to cause negative impacts on your thoughts or behaviors.

Periactin is gaining popularity among customers because of the clear health advantages it provides. While researching and writing this page, we discovered no relevant medical cautions. This drug should be taken only when plainly necessary during pregnancy. Alcohol and sugar may be present in liquid items. If you have diabetes, liver illness, and any other disorder that requires you to avoid or restrict these in your diet, proceed with caution. However, if you face any problems after taking medicine, you should consult professional medical care right once.


What do I need to consider if I want to discontinue Periactin?

If you have been using Periactin for a long period, do not suddenly discontinue them. This might result in unpleasant withdrawal symptoms, including nausea, vomiting, and sleep disturbances. If these drugs must be stopped, doctors normally lower the dose slowly before stopping the medication.

Note that Periactin is only one component of treating allergy symptoms. Other treatments, like exercise and physical therapy, epidural steroid injections, and workplace lifestyle changes, may be prescribed by your doctor to prevent it.

Where can you buy Periactin over the counter? Periactin price comparison & deals for sale:

Periactin is used to treat a wide range of allergic reactions. This drug is available in tablet and syrup (liquid) versions and is appropriate for persons aged two and above. Periactin is less widely used since it produces greater sleepiness and other adverse effects than other allergy drugs, including loratadine, cetirizine, and fexofenadine.

Some online shop is selling this for the most common variant of generic Periactin is roughly $11.70, which is around 78 percent less than the average retail price of $53.77.

You cannot get Periactin without a valid prescription since these medications require a valid prescription. You may, however, acquire generic Periactin without a prescription from internet pharmacies.

Can you buy Periactin in a pharmacy?

Obviously, Periactin is widely available at pharmacies around the country. Furthermore, the medicine is readily available and needed by law, so you may get it at your local pharmacy. However, you must always have a valid prescription to purchase them. If you want to avoid submitting a prescription, it is strongly advised to purchase it from an online retailer.

Can you buy it in pharmacy?

Periactin Review Conclusion - Our experience and recommendation:

Periactin is an antihistamine that is taken orally and is used to treat allergic responses. It is classed as a first-generation antihistamine since it operates by suppressing the effects of histamine. Histamine is actually produced by cells in the body during allergic responses and, to a lesser extent, during viral infections such as the common cold. When histamine binds to receptors on some other cells, it produces internal changes that lead to the release of chemicals that can cause itching, sneezing, and mucus secretion. Antihistamines compete for cell receptors with histamine and attach to them without activating the cells.

Keep a note of everything you use and talk to your pharmacist or doctor about it. Do not begin, discontinue, or change the dosage of any drugs without first contacting your doctor.

Store at room temperature, away from direct sunlight and humidity. Stay away from the restroom. Keep all medications out of the reach of children and pets.

This medication has been precisely prescribed for your current condition. Do not use it for any other condition unless your doctor directs you to. In that case, a different medication may be necessary.

People should not be afraid of the material as it has been thoroughly researched and tested by reputable laboratories before using it. If you just want to refuse a fake purchase, always buy from a trusted source. Therefore, Periactin is a great antibiotic that helps you gain weight and get rid of all kinds of allergic conditions.

experience and recommendation

Frequently asked questions about Periactin:

What is Periactin?

What does Periactin do?

How to take Periactin?

How much does Periactin cost?

Where can I buy Periactin without a prescription?

Are there any criticisms of Periactin, or is it recommended to take Periactin?

Does Periactin have any risks or side effects?

Is it safe to take Periactin continuously?

Do I need a prescription to buy Periactin?


Written by Dr. Dana Kim
Medical Writer & Editor

Dr. Dana Kim is a clinical pharmacist. She earned her doctorate in pharmacy from the University of Illinois at Chicago. She has worked as a home infusion pharmacist and has written clinical communications for patients and professionals for more than ten years. Dr. Kim is also a Writer for

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